D-threo-PPMP hydrochloride

D-threo-PPMP is a glucosylceramide (GlyCer) synthetase inhibitor.1,2It is the active enanantiomer and enzymatic inhibitory component of the racemic DL-threo-PPMP . In MDCK kidney epithelial cells, D-threo-PPMP induces a 70% reduction in cell growthin vitroat 20 μM and significantly inhibits DNA synthesis at 3 μM.3[Matreya, LLC. Catalog No. 1865] 1.Shen, W., Henry, A.G., Paumier, K.L., et al.Inhibition of glucosylceramide synthase stimulates autophagy flux in neuronsJ. Neurochem.129(5)884-894(2014) 2.Lee, L., Abe, A., and Shayman, J.A.Improved inhibitors of glucosylceramide synthaseJ. Biol. Chem.274(21)14662-14669(1999) 3.Abe, A., Inokuchi, J.-i., Jimbo, M., et al.Improved inhibitors of glucosylceramide synthaseJ. Biochem.111(2)191-196(1992)

D-3263 hydrochloride (D3263 HCl salt) is enteric-coated, orally bioavailable transient receptor potential melatonin member 8 (TRPM8) agonist.

D(+)-Galactosamine hydrochloride (D-Galactosamine HCl) hepatotoxicity is associated with endotoxin sensitivity and mediated by lymphoreticular cells in mice.

D-Carnitine hydrochloride ((S)-Carnitine Hydrochloride) is a component of striated muscle and liver, used therapeutically to stimulate gastric and pancreatic secretions and to treat hyperlipoproteinemias.

D-Ornithine monohydrochloride is an endogenous metabolite that regulates intramuscular hormone levels, and has been used in studies of dry skin and insomnia.3,5-Dihydroxybenzoic acid is an endogenous metabolite that regulates intramuscular hormone levels.

2’-Deoxy-2’-fluoro-β-D-arabinocytidine hydrochloride is a cytosine nucleoside analog with inhibitory effects on DNA methyltransferase , with potential antimetabolic and antitumor activity.

L-threo-PPMP is an inhibitor of GlcT, which is the UDP-Glc: Ceramide β1,1glucosyltransferase enzyme. It effectively inhibits glycosphingolipid biosynthesis, while also inducing apoptosis. These properties of L-threo-PPMP contribute to its notable anti-cancer activity.

1,4-Dideoxy-1,4-imino-D-arabinitol (DAB) functions as an inhibitor of glycogen phosphorylase, a crucial enzyme in glycogenolysis, demonstrating the ability to hinder this process in isolated liver cells (IC50= 1.0 µM) and cerebral cortex and cerebellum homogenates (IC50s = 463 and 383 nM, respectively). Employed extensively in different animal models, DAB inhibits glycogenolysis within the liver and brain.

D-Ala-Lys-AMCA hydrochloride, a known substrate of proton-coupled oligopeptide transporter 1 (PEPT1), emits blue fluorescence and may be transported into Caco-2 cells and liver cancer cells.

rac threo-Dihydro Bupropion-d9 Hydrochloride is a deuterated compound of rac threo-Dihydro Bupropion Hydrochloride. rac threo-Dihydro Bupropion Hydrochloride has a CAS number of 1396889-62-5.

D-Alanine ethyl ester hydrochloride (T66104, CAS 6331-09-5) is a valuable organic compound for life sciences research.

D-Leucine methyl ester hydrochloride is a useful organic compound for research related to life sciences. The catalog number is T66885 and the CAS number is 5845-53-4.

C8 D-threo Ceramide is a bioactive sphingolipid and cell-permeable analog of naturally occurring ceramides. It is cytotoxic to U937 cells (IC50 = 17 μM) and induces nuclear DNA fragmentation 5- to 6-fold more potently than C8 ceramide . C8 D-threo Ceramide is a substrate for E. coli diacylglycerol kinase. It activates ceramide-activated protein kinase (CAPK) in U937 cells. C8 D-threo Ceramide also enhances V. cholerae cytolysin pore formation in liposome lipid membranes, as measured by calcein release, with a 50% release dose (RD50) value of ~5 μg/ml.

(-)-L-threo-PDMP is an enhancer of ganglioside biosynthesis. The (-)-L-threo-PDMP (1S,2S) isomer is the active stimulatory component of DL-threo-PDMP in contrast to (+)-D-threo-PDMP , which is an inhibitor of glucosylceramide synthetase. (-)-L-threo-PDMP upregulates GM3, GD3, and GQ1b synthase levels, which are glycosyltransferases involved in ganglioside biosynthesis, and increases ganglioside levels in cells. It increases neurite outgrowth and synapse formation in vitro and improves retention of a long-term memory learned prior to forebrain ischemia in rats when administered following ischemia at a dose of 40 mg/kg per day.

N(G)-Nitro-D-arginine methyl ester (D-NAME) is the less active enantiomer of the nitric oxide (NO) synthase inhibitor N(G)-nitro-L-arginine methyl ester . D-NAME was initially thought to be inactive and was often used as a negative control for L-NAME. Later studies showed that D-NAME (40 mg/kg/day in rats) can have similar but less pronounced effects as L-NAME (40 mg/kg/day in rats) in the cardiovascular system, particularly at long-term timepoints. D-NAME (3-10 µg/mouse) had no effect on nociception in mice assessed using the tail flick test.

(+)-D-threo-PDMP is a ceramide analog and is one of the four possible stereoisomers of PDMP . (+)-D-threo-PDMP is an inhibitor of glucosylceramide synthase. It inhibits glucosylceramide synthase by 50% when used at a concentration of 5 μM in an enzyme assay. (+)-D-threo-PDMP is the active component of racemic DL-threo-PDMP .

cis-4-Hydroxy-D-proline hydrochloride (catalog number T66933, CAS number 77449-94-6) is a valuable organic compound for research in life sciences.

D-Proline, 4-hydroxy-, methyl ester hydrochloride (T65606, CAS 114676-59-4) is a valuable organic compound for life sciences research.

D-threo Sphinganine (d18:0) is a synthetic bioactive sphingolipid and stereoisomer of sphinganine (d18:0) and L-erythro sphinganine (d18:0) . It induces autophagy in HCT116 cells when used at a concentration of 12 μM. D-threo Sphinganine (d18:0) is metabolized via sphinganine N-acyltransferase and sphinganine kinase in vivo in rat liver.

D-threo-PPMP, a powerful glucosylceramide (GlcCer) synthase inhibitor, effectively impedes karyokinesis and decreases cyst formation.

9-(2-Deoxy-beta-D-threo-pentofuranosyl)adenine is a Nucleoside Derivative - Xylo-nucleoside.

D-Homophenylalanine ethyl ester hydrochloride is a useful organic compound for research related to life sciences. The catalog number is T66011 and the CAS number is 90940-54-8.

2-Amino-6-(propylamino)-5,6-dihydrobenzo[d]thiazol-7(4H)-one hydrochloride is a useful organic compound for research related to life sciences and the catalog number is T64682.

.trans-4-Hydroxy-D-proline methyl ester hydrochloride (catalog number: T65562, CAS number: 481704-21-6) is a valuable organic compound for life sciences research.

Nucleoside Derivatives - Xylo-nucleosides; Protected nucleosides w/NH2/OH open

D-erythro-Sphingosine hydrochloride, also known as Erythrosphingosine, serves as a specific TRPM3 activator and induces retinoblastoma protein dephosphorylation.

D-Cl-amidine hydrochloride, a potent and highly selective inhibitor of PAD1, exhibits excellent tolerance and does not induce significant toxicity [1].

C6 D-threo Ceramide is a bioactive sphingolipid and cell-permeable analog of naturally occurring ceramides., C6 D-threo Ceramide is cytotoxic to U937 cells in vitro (IC50 = 18 μM). It is metabolically inactive and, unlike C6 L-erythro ceramide , C6 D-threo ceramide cannot be converted to C6 glucosylceramide by ceramide glucosyltransferase. C6 D-threo Ceramide promotes survival of isolated rat spinal neurons when used at concentrations up to 2.5 μM but induces cell death at concentrations greater than 5 μM. It enhances IL-4 production induced by phorbol 12-myristate 13-acetate in EL4 T cells when used at a concentration of 10 μM.

3-Azido-D-alanine hydrochloride, an azido-modified derivative of D-alanine hydrochloride, serves as a reagent in click chemistry labeling research [1].

N2-Fmoc-D-lysine Hydrochloride is a useful organic compound for research related to life sciences. The catalog number is T65188 and the CAS number is 201002-47-3.

D-methionine sulfoxide hydrochloride is the D-isomer of methionine sulfoxide hydrochloride, the oxidation product of methionine, a restrictive amino acid in milk or legume proteins that is easily oxidized during storage or processing.

D-2-Aminoglutarimide is a synthetic intermediate.1It has been used in the synthesis of hydantoins with anti-angiogenic and cancer cell differentiation-inducing activities. 1.Yamaguchi, J., Noguchi-Yachide, T., Sakaguchi, Y., et al.Synthesis of new hydantoins bearing glutarimide or succinimide moiety and their evaluation for cell differentiation-inducing and anti-angiogenic activitiesHeterocycles91(4)764-781(2015)

D-threo-PDMP is a potent inhibitor of glucoceramide synthase (GCS), effectively reducing cell surface glycosphingolipids by inhibiting glycosylation. Additionally, it decreases the axon plexus's total length and the number of axon branch points, ultimately inhibiting neurite growth.

4,5,6,7-Tetrahydro-1H-benzo[d]imidazole-5-carboxylic acid hydrochloride is a useful organic compound for research related to life sciences. The catalog number is T66049 and the CAS number is 131020-57-0.

H-D-Phe-Pip-Arg-pNA hydrochloride, a chromogenic substrate, mimics the N-terminal segment of the A alpha chain of fibrinogen, the native substrate of thrombin. It is specific to thrombin and is used for quantifying antithrombin-heparin cofactor (AT-III), enabling a sensitive, accurate, and straightforward AT-III assay.

trans-4-Hydroxy-D-proline hydrochloride, with catalog number T65471 and CAS number 142347-81-7, is a valuable organic compound for life sciences research.

D-Mabuterol hydrochloride is a D isoform of Mabuterol, which is a selective β2 adrenoreceptor agonist. Mabuterol has been found to decrease the blood pressure in rats and increase heart rate and contractile force in guinea pigs. Mabuterol inhibited the positive inotropic effect of isoprenaline but has no effect on alpha-adrenergic, acetylcholine and histamine receptors.

Bz-D-Arg-pNA hydrochloride is a competitive inhibitor of trypsin.

C18 D-threoCeramide (d18:1/18:0) is a synthetic ceramide and stereoisomer of C18 ceramide .1It inhibits rat brain mitochondrial ceramidase (mt-CDase) with an IC50value of 16.6 μM.2[Matreya, LLC. Catalog No. 1855] 1.Koolath, S., Murai, Y., Suga, Y., et al.Chiral combinatorial preparation and biological evaluation of unique ceramides for inhibition of sphingomyelin synthaseChirality32(3)308-313(2019) 2.Usta, J., El Bawab, S., Roddy, P., et al.Structural requirements of ceramide and sphingosine based inhibitors of mitochondrial ceramidaseBiochemistry40(32)9657-9668(2001)

1-Amino-1-deoxy-D-fructose is an amino monosaccharide.1It induces site-specific DNA damage at pyrimidine residues in cell-free assays. 1-Amino-1-deoxy-D-fructose moieties have been found as a component of fructosamines, glycated serum proteins that are elevated in patients with conditions such as diabetes.2,3

D,L-erythro-PDMP hydrochloride, an erythro isomer of PDMP, inhibits the growth of cultured rabbit skin fibroblasts and serves as an effective inhibitor of UDP-glucose:ceramide glucosyltransferase.

Lysosphingomyelin is an endogenous bioactive sphingolipid and a constituent of lipoproteins.1,2It is produced by the removal of the acyl group from sphingomyelin by a deacylase and acts as a precursor in the biosynthesis of sphingosine-1-phosphate . D-erythroLysosphingomyelin is an agonist of the S1P receptors S1P1, S1P2, and S1P3(EC50s = 167.7, 368.1, and 482.6 nM, respectively, for the human receptors).3It is also an agonist of the orphan receptor ovarian cancer G protein-coupled receptor 1 (ORG1) that induces calcium accumulation in cells overexpressing OGR1 (EC50= ~35 nM).4Levels of D-erythrolysosphingomyelin are increased in skin isolated from patients with atopic dermatitis, as well as postmortem brain from patients with Niemann-Pick disease type A, but not type B.2,5L-threolysosphingomyelin is also an S1P1-3agonist (EC50s = 19.3, 131.8, and 313.3 nM, respectively).3This product is a mixture of D-erythroand L-threolysosphingomyelin. [Matreya, LLC. Catalog No. 1321] 1.Ito, M., Kurita, T., and Kita, K.A novel enzyme that cleaves the N-acyl linkage of ceramides in various glycosphingolipids as well as sphingomyelin to produce their lyso formsJ. Biol. Chem.270(41)24370-24374(1995) 2.Nixon, G.F., Mathieson, F.A., and Hunter, I.The multi-functional role of sphingosylphosphorylcholineProg. Lipid Res.47(1)62-75(2008) 3.Im, D.-S., Clemens, J., Macdonald, T.L., et al.Characterization of the human and mouse sphingosine 1-phosphate receptor, S1P5 (Edg-8): Structure-activity relationship of sphingosine1-phosphate receptorsBiochemistry40(46)14053-14060(2001) 4.Meyer zu Heringdorf, D., Himmel, H.M., and Jakobs, K.H.Sphingosylphosphorylcholine-biological functions and mechanisms of actionBiochim. Biophys. Acta1582(1-3)178-189(2002) 5.Rodriguez-Lafrasse, C., and Vanier, M.T.Sphingosylphosphorylcholine in Niemann-Pick disease brain: Accumulation in type A but not in type BNeurochem. Res.24(2)199-205(1999)

H-D-Aha-OH (hydrochloride), a click chemistry reagent, contains an azide group.